Depressed? Don’t take Antidepressants

Recently, a study was published in the Journal of the American Medical Association that showed that anti-depressants are no more effective for depression than a sugar pill (a placebo).  In fact, if you take into account the side effects that a person might experience while taking an antidepressant you could say that taking the medication was actually worse than taking nothing at all.  At $4 per pill, that is an expensive way to not treat depression.

There is no doubt that depression is a serious and sometimes debilitating condition.  I have many patients who complain from time to time they feel a little (or a lot) down.  About 9.5% of the American public is affected by some form of depression.  That’s almost 19 million people!  If you’re a pharmaceutical company that is also quite the market for a product.  From a business standpoint, I can understand their desire to push through products that could potentially tap into this.

There are many patients, however, that swear they have gotten help by taking one of several prescription antidepressants available.  They swear up and down that they had no preconceived notions or expectations as to whether the drug was going to work for them.  While this may be true, the participants in the studies also felt the same way because they knew there was a chance they might receive a dummy pill.  Patients who speak to their doctors about depression are looking for treatment.  They are hoping that something can be done to help improve their mood.  Whether they expect the medication to work for them is irrelevant.  The very fact that they seek treatment makes the placebo effect a very real possibility, despite their rationalizations.  Hope is not rational.

The next argument for antidepressants (an all drugs for that matter) is that the FDA would not approve a drug that doesn’t work or isn’t safe.  Consider what it takes for a drug to get approved.  It is not as difficult as it may seem.

The FDA requires two well-designed clinical trials showing a drug is more effective than a placebo. That’s two, period—even if many more studies show no such effectiveness. And the size of the “more effective” doesn’t much matter, as long as it is statistically significant. (From Newsweek)

Yes, you read that correctly.  A drug may have 10 studies that shows it is ineffective and just 2 that shows it works and it will get approved.  I wonder if the pharmaceutical industry had anything to do with “helping” write those requirements?

People want to believe that these drugs are helpful.  They scoff, “If these antidepressants are not better than placebo, then how come I have heard this before?” Consider the power and reach of the pharmaceutical industry.  Antidepressants are a $9.6 billion dollar industry.  They’ve got money and power to suppress people a research that may be unfavorable.  The story of psychology researcher Irving Kirsch is a good example.

The boy who said the emperor had no clothes didn’t endear himself to his fellow subjects, and Kirsch has fared little better. A nascent collaboration with a scientist at a medical school ended in 2002 when the scientist was warned not to submit a grant proposal with Kirsch if he ever wanted to be funded again. Four years later, another scientist wrote a paper questioning the effectiveness of antidepressants, citing Kirsch’s work. It was published in a prestigious journal. That ordinarily brings accolades. Instead, his department chair dressed him down and warned him not to become too involved with Kirsch. (From Newsweek)

These stories abound in research when it is unfavorable to corporate conglomerates like pharmaceutical companies.  They fund research, but not so they can remove products from the market.  They want more product.  Anything that is unfavorable is frowned upon and researchers who insist on truth are not funded.

So the next question I get is, “Then what am I supposed to do about my depression.” Do anything.  That’s right, anything other than antidepressants.  The placebo effect improves mood because the person thinks they are doing something to improve it.  And who cares?  If you decide you want to stand on your head and sing happy birthday and it improves your mood, the end result is achieved.  Placebo effect or not, you feel better.  There are things, however, that I recommend to my depressed patients to help them out of their depression.

  • I always recommend a healthy diet.  You must eat well to feel well.  Garbage in equals garbage out.
  • Exercise, exercise, exercise.  There is sound research that exercise is the number 1 cure for depression lasting less than 7 years.
  • Change your thought pattern.  In neurology there is a term called “top-down plasticity.”  Essentially what it means is that your thoughts change the wiring in your brain.  Learning about cognitive behavioral therapy or a similar discipline is often helpful.
  • Take supplements.  A balanced neurotransmitter system is important.  I routinely measure these in a urine and saliva test.  Many times serotonin is low, but not always.  We recommend our amino acid therapy based on these neurotransmitter tests.
  • Manage your stress levels.  Stress can produce a hormonal imbalance that is unfavorable for healthy mood.
  • Sleep well.  Getting enough restful sleep is also important.  There are many factors that play into sleeping well, but keeping a regular sleep schedule is a good start.

There are many effective ways to manage depression without resorting to pharmaceutical agents which can often result in side effects that are just as bad or worse than the symptoms of depression.  The research is pretty convincing that they are not very effective.  Don’t buy into the hype.  Just because it’s on TV doesn’t mean it’s true.

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7 Comments

Filed under Big Pharma, Brain Health, Public Health

7 responses to “Depressed? Don’t take Antidepressants

  1. Andy Perry

    What are your references and credentials? I noticed that none are stated by a medical professional. I would say that the above article is completely irresponsible. I know people who would not function without medication. I also know some personally that have not benefited much from them.

    • Shelly

      Why do you have to have a specific degree to be knowledgeable? What about good old anectodal evidence? If you simply google “Effexor withdrawl” you get 1,560,000 results where desperate victims are pleading for help trying to get off the poision which has caused them to have suicidal feeling, brain zaps, anger, body aches etc which they NEVER had before they took the drug. It is not simply Effexor, it is all of them. Please take the poison YOURSELF and come back and tell us how that’s working for you. Feed up with ignorance.

    • Tony

      Where is the scientific proof behind all of these diagnosis? You need don’t to be a medical profession to state these; psychiatrist are not medical professionals either they don’t have any medical test to diagnosis these disorders.

  2. Genevieve

    Andy,
    There is significant evidence to support that anti-depressants are an effective treatment for depression. But there is also significant evidence to show that other options are healthier and much more responsible. It is a cop out to say that they could not function without medication. If you do research of your own on the topic you can find “medical professionals” to defend both arguments. So who is more credible? Both could be right or wrong, the point is to make the decision for yourself. If someone is depressed maybe they could try some of the things on the list of suggestions before pursuing medications.

  3. trinkwasser

    Sorry, don’t agree with this one at all!

    My experience is that different classes of drug have significantly differing effects. SSRIs don’t work well and then stop. Tricyclics work well but with side effects. Effexor works nearly as well but without side effects. Yet I know people who have exactly the opposite results. In fact I know many people whose responses differ so significantly that placebo effect cannot be a factor. There was a study that showed no single drug had more than 60% efficacy over placebo but over all medications and combinations somewhere over 85% of patients gained relief.

    Why? – basically because “depression” is a catch-all for a bunch of similar but differing conditions. Mine is less related to serotonin and more to norepinephrine and dopamine levels and the symptoms are like an enhanced hibernation response (SAD), I am never suicidal or manic and seldom hypermanic (“Atypical” depression comes closest).

    I certainly agree there are many other treatments that *may* help – for example my symptoms improved hugely once I discovered they are related to my cycling blood glucose and made that stop. Vitamin D status is probably a factor since it’s often chronically low and drops further in winter. Imbalance of fatty acids (excess Omega 6 and insufficient Omega 3) and especially trans fats are implicated in damaged neuroreceptors. Thyroid is often a factor in “treatment-resistant” depression: our local lab considers TSH of 4.2 to be “normal”.

    By sorting out these other problems I’ve reduced my venlafaxine dose to 1/6 of what it was (I generally need to double this for a while in winter) but I have NO intention of stopping the stuff ever again! If the drugs are used at insufficient dose for insufficient time (which was done to me in the past) they are ineffective and may result in the depression returning in more intractable form: one way they can be made to appear ineffective in trials, as some of the Scientologist-backed research demonstrates.

  4. Mike

    Honestly, the best cure for depression: MEDITATE!!! I am living proof. Before you try anything else try meditating on a regular basis and work on observing thoughts and the ego. I guarantee you will feel better in just a few weeks!

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