4 Substances That Slow The Aging Process

Animation of the structure of a section of DNA...

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Anti-aging is a large field in medicine.  Most of the diseases that human beings suffer from significantly increase as we age.  The theory is that if we can slow down the aging process we can live longer, more disease free lives.

Individual cells can live forever in the laboratory.  It’s been done.  This is a fascinating fact .  However, human beings are multicellular organisms and each cell does not live in isolation.  Further, cells that live forever in the laboratory live in ideal conditions.  They are not exposed to chemicals, hormones or undergo the same physical stresses that we do on a day to day basis.  But, the fact remains – a biological system, given the best possible scenario, can live forever.  So what if there were things we could do to slow the aging process?  We may not be able to live forever, but could we significantly increase our life spans?  The answer is yes.  There are several known substances that have a positive effect on the aging process that are available to everyone in supplement form.

Aging

Aging is a genetic process and a free radical induced process.  First, our genes are important.  It is helpful if Mom and Dad lived to be 100, but it is not essential.  Our DNA is stored in each cell in the nucleus.  Within this nucleus are the chromosomes that contain all of the DNA we were born with.  We get 23 chromosomes from each of our parents for a total of 46.  Every single cell in the body has an identical copy of these genes.  Each chromosome is shaped roughly like an X.  The ends of these chromosomes are called telomeres.  These telomeres are interesting in that they shrink as we age.  There are known substances that slow the shortening of these telomeres and therefore slow the aging process.

Free radical damage is also another way that people age.  Free radicals are potent molecules that bounce around in our bodies and break down our cells.  The theory is that the human body can only repair so much and this damage begins to accumulate over time causing us to age.  Now, it would make sense if we just avoided these free radicals wouldn’t it?  It would if we could.  Some of the most potent free radicals are nitrogen and oxygen which happen to make up 78% and 21% of the air we breath respectively.  Our diets are designed to help us fight this battle because we can consume antioxidants.  This class of nutrients fights free radical damage but it cannot win the war.  There are, however, compounds that are known to be powerful free radical scavengers and should be consumed on a more regular basis to slow the aging process.

Supplements That Slow Aging

Resveratrol

Resveratrol is a magnificent substance.  It is found in many things, but mainly in the skins of grapes.  It is also why red wine (in moderation) seems to have such great health benefits.  Resveratrol activates something called sirtuins.  Sirtuins are genes (known as SIRT1 though SIRT8) that function to repair breaks in our DNA strands that occur as we age.  These sirtuins also play a key role in maintaining the length of the telomeres discussed earlier.  Sirtuins also act to regulate inflammation in the body by inhibiting something called NF-KappaB.  This is a potent inflammatory enzyme that is responsible for many disease processes in human beings.  Resveratrol also decreases the production of adhesion molecules that attract inflammatory cells to our vessel walls and therefore inhibits atherosclerosis.  These adhesion molecules also promote the spread of cancer.  Taking resveratrol is easy but be sure when you buy a supplement it is of high quality and contains trans-resveratrol.  All other forms are useless to take.

Pterostilbene

This substance is very similar to resveratrol but it is found in blueberries.  It works with resveratrol in multiple complimentary mechanisms to limit NF-KappaB.  This is not available in supplement form, but you can certainly get it from eating as many blueberries as you’d like!

Quercetin

This magnificent substance protects against such diseases as asthma, inflammatory bowel disease and arthritis.  It has also been shown to help modulate blood sugar levels in diabetics and non-diabetics.  Blood sugar control is extremely important for longevity.  Quercetin acts by also inhibiting NF-KappaB.  This is also available in supplement form and is sometimes paired into one supplement with resveratrol.

Grape Seed Extract

This helps to regulate pro-inflammatory cytokine activity in fat cells.  It helps combat obesity and type II diabetes.  It also triggers genes for glucose uptake.  This assists cells in the absorption and removal of glucose from circulation.  This substance is very readily available in supplement form.

The research into longevity is quite interesting and there are many substances that can slow the aging process, not just the ones above.  Of course, you must also watch your diet and exercise to get all of the wonderful benefits that the above provide.  If you do those things and take these life lengthening substances you will live and longer and happier life.

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1 Comment

Filed under Diet, Public Health

One response to “4 Substances That Slow The Aging Process

  1. Pingback: Triple Treat « Hot Tips, News and Trends for Healthy Aging By Dr. Joel Lopez, M.D.

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