Tag Archives: Alzheimer’s disease

Coffee Wards Off Dementia!

In a new study published in the Journal of Alzheimer’s Disease participants with mild cognitive impairment who had a certain level of caffeine in their blood did not go on to develop dementia.  This is the first study to attempt to isolate whether it’s just coffee that’s protective in dementia or if it is indeed the caffeine that imparts the benefit. In this case, the caffeine seems to be the protective variable.  See the video below for more.

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What is Preventative Health Care?

The importance of preventative health care cannot be overstated.  Five of the top six leading causes of death in the United States are preventable diseases through diet an exercise. The only leading cause of death that isn’t preventable is accidents.  If we want to reduce the cost we all pay for insurance premiums and health care, we need to start paying attention to how to reduce chronic disease before it starts.

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Fish Oil Protects the Aging Brain!

More great information on fish oil! In addition to recent reports that fish oil is a valuable and effective tool in the management of ADHD, heart arrhythmias, anxiety and inflammation, a new study found that omega-3s protect against an aging brain.  Check out the video below.

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Alzheimer’s Disease video blog

Below is another video blog.  This time we’re talking about Alzheimer’s disease and what you can do to reduce your risk of developing this devastating condition.  Enjoy!

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Mummies had heart disease

An Egyptian mummy kept in the Vatican Museums.

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Even the ancient Egyptians had heart disease.  I’m not sure why this is such a surprise, but the researchers who conducted the study seemed to be very surprised.

Traditional medical thinking on heart disease goes like this; heart disease is caused by eating too much fat, mainly from meat, and a sedentary lifestyle.  That’s basically it.  Yes, there are other risk factors to take into consideration like smoking, high blood pressure, diabetes, etc, but talk to your average medical doctor and they will tell you that eating high levels of animal fat coupled with too much TV is a recipe for disaster.

I couldn’t disagree more and this new study confirms my thoughts.  I agree that lack of exercise is a big issue with heart health.  That one is not debatable.  I also agree that smoking, high blood pressure and diabetes are big players.  I disagree that eating too much animal fat is a problem.

Dr. Greg Thomas is part of a team of scientists that recently discovered the earliest known case of atherosclerosis — clogged arteries — in ancient Egyptian mummies.

Dr. Thomas said, “Our hypothesis was that they wouldn’t have [heart disease], because they were active, their diet was much different, they didn’t have tobacco.”

One of the mummies the team scanned was a princess in her 40s, who presumably ate fresh food and wasn’t sedentary. “That she would have atherosclerosis,” Thomas says, “I think we’re missing a risk factor.”

According to scientists the ancient Egyptians had access to meat, but not a lot of it.  Their diet consisted mainly of fruits, vegetables and grain.

Perhaps the problem isn’t meat.  I would contend that a diet high in grains, as is the case with the pharaohs, could lead to atherosclerosis.  Grains are high in the inflammatory group of fatty acids called omega-6.  Meats are also high in omega-6s.  The difference? When grains are consumed the hormone insulin is secreted which funnels all of the omega-6s in that meal into a very potent pro-inflammatory pathway.  It is this inflammation that leads to heart disease.  When one consumes animal fat no insulin is secreted thereby allowing those omega-6s to actually be driven into a protective and anti-inflammatory pathway.

I also have a problem with the assumption that a princess in ancient Egypt was not sedentary.  If you look throughout history, the upper class has been historically, well, lazy.  They’ve had slaves, servants and serfs to do everything for them.

The combination of low activity levels and a diet high in grain leads people to be unhealthy.  A person does not need to be overweight to be unhealthy either.  There are plenty of people in this country who are considered to be ‘healthy’ in terms of body weight but are actually not very healthy at all.

In my opinion, the fact that an ancient Egyptian princess had atherosclerosis is not earth shattering.  Human physiology has not changed over the last 2,000+ years.  A diet that is high in grains, whole or otherwise, will lead to a pro-inflammatory state.  This pro-inflammatory state will lead to heart disease, cancer and Alzheimer’s to name a few.

If you want to avoid heart disease, or any other inflammatory disease for that matter, make sure grains are a smaller part of your diet.  Get your carbohydrates from fruits like berries and eat plenty of vegetables.  Make sure you consume plenty of protein as well.  Eat the diet of our ancestors from 10,000 years ago not 2,000.  That’s before human beings learned to cultivate grain, mill it and refine it.  Once that happened, as was the case in ancient Egypt, inflammatory diseases began to rise including atherosclerosis.

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Genes, Alzheimer’s Disease and Your Choice

PET scan of a human brain with Alzheimer's disease

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New genes have been discovered that seem to be linked to Alzheimer’s Disease (AD).  AD currently affects over 5 million Americans and that number is expected to increase substantially by the year 2029.

This year the first baby boomers will reach their 65th birthdays. By 2029, all baby boomers will be at least 65 years old.  Ninety-five percent of all AD is in people 65 and older.

The discovery of new genes linked to AD is a step in the right direction.  Every bit of information that help scientists unlock the mystery of why this occurs puts us closer to being able to effectively treat AD.

Let’s pretend that we know every gene that is involved in the production of AD.  Let’s also pretend a test that exists to specifically detect all of these genes in you.  Would you want to find out?  What would you do if you had all of the genes linked to AD?

The truth of it is, there is nothing you could do to change your genes.  Your genes are your genes.  They are there and you can’t remove them.  What you can do, however, is change how they are expressed.  Just because a person has a specific gene does not mean it has to be expressed.  The expression of many of our genes is closely related to our environment.  Diet, exercise, smoking, pollution and stress are just a few things that can negatively or positively affect the expression of our genes.

So back to my first question.  What would you do if you had all the genes linked to AD?  You can’t change your genes, but you can change your risk factors.

There are many known risk factor that increase the risk of AD, independent of your genetic potential.  The number one risk is aging.  Unfortunately, there isn’t much that can be done about that.  We are all going to get older which is not necessarily a bad thing.  It is much better than the alternative!

Known risk factors for AD that are controllable are as follows:

You will notice that these risk factors significantly overlap with one another.  You will also notice that when you control one risk factor you will impact another.  If you can control these risk factors in your life you will significantly reduce your risk of developing AD regardless of your genetic potential.
Cardiovascular health is perhaps the most important.  Cardiovascular disease causes a chronic, low grade reduction in blood delivery to the brain.  This is known as hypoperfusion.  This hypoperfusion is responsible for protein synthesis defects that later result in the classic AD neurodegenerative lesions.

To keep your cardiovascular system as healthy as possible make sure you eat an anti-inflammatory diet and exercise.  Fish oil is also something you should consider.  Fish oil, which contains omega-3 fatty acids, has been shown to reduce cardiovascular disease mortality better than any other substance known.

Reduction of high blood pressure is also very important.  When blood pressure is too high it fuels a kind of scarring linked to later development of Alzheimer’s disease and other dementias.  Controlling your blood pressure is actually very simple.  You must maintain a healthy weight first and foremost.  This, of course, means diet and exercise.  Increasing waistlines mean more tissue and blood vessels for your heart to push blood through. This puts a strain on the heart and increases the resistance the heart must push against.

Keeping a healthy cholesterol profile is essential.  However, the traditional tests from your doctor are probably not enough to tell whether you are at risk or not.  Traditional tests examine total cholesterol, HDL (“good”), LDL (“bad”) and triglycerides.  These are of some value, but they don’t tell the whole story.  What you must find out is the particle size.  In a nut shell, large and buoyant molecules of cholesterol are not as problematic as small and dense particles.  Your traditional test does not distinguish between the two.  Your traditional test might look very good, but a more advanced test may show that you are still very much at risk.  See my blog entry from last summer for more detailed information.

Diabetes is also extremely important to control.  Some references are referring to Alzheimer’s as Type III diabetes because of the biochemical similarities. Even being borderline diabetic raises the risk of developing Alzheimer’s or dementia by 70%!  Diabetes’ hallmark is high blood sugar.  This high blood sugar leads to a phenomenon called advanced glycation end products or AGEs.  AGEs adversely affect the structure and function of proteins. In combination with oxidative stress brain function is easily affected.  Advanced glycation end products have been found to be much more prevalent in the brains of Alzheimer’s patients than in healthy controls. This process begins early on in the course of Alzheimer’s and there is also evidence that AGEs assist in the formation of plaques seen in AD.  Diet and exercise are the best ways to prevent diabetes and reduce your risk of AD.

While the study for a purely genetic link to AD will continue, a cure is likely many years away if one can even be found.  What we can control, however, are our lifestyle choices that activate our genes.  If we choose poorly, we are much more likely to activate unfavorable genes that cause disease.  If we choose wisely, we are more likely to activate genes that are favorable and reduce our risk of further disease.  The choice is yours.  Make the right one.

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Reducing Your Risk of Alzheimer’s Disease Naturally

PET scan of a human brain with Alzheimer's disease

Image via Wikipedia

As of next year the first of the baby boomers will reach 65 years old and by 2029 all of them will be at least 65.  This is significant because as we age certain diseases become more and more prominent.  One of them is Alzheimer’s disease.  This disease robs people of the faculties much too soon and causes heartache and financial hardship for families across the US.

Just How Big Is The Problem?

About 24 million people worldwide are known to be affected with dementia. This number is expected to balloon to 84 million by the year 2040.  These numbers include all forms of dementia, but up to 80% of dementia is caused by Alzheimer’s disease (AD).  In the US alone 5.3 million American’s have Alzheimer’s Disease and 96% of them are over the age of 65.  In just five years the number of Americans with Alzheimer’s will jump to 7.7 million and by 2050 the number is projected to more than double to 16 million.  The numbers truly are staggering.  As a matter of fact, AD has recently passed diabetes, yes diabetes, as the 6th most common cause of death in the US.  As our population continues to grow older because people are living longer, the problem is likely to get worse.  Current statistics show that just over 50% of people who are over 85 will go on to develop AD.

AD is also a very expensive problem for the United States.  In 2005, total Medicare spending was $91 billion and the total US cost was $172 billion for AD.  AD patients make up roughly 13% of Medicare enrollees but account for more than 1/3 of its spending.  The problem will only grow as our population ages.

So What Can I Do To Reduce My Risk?

The best way to treat AD is to prevent it in the first place.  There is very good research behind several nutritional supplements that can significantly reduce your risk of developing dementia as you age.

Vitamin E

Here’s what one study found on vitamin E:

“Among MCI-AD patients, the longitudinal decrease in cellular vitamin E was associated with the deterioration in cognitive performance. These results suggest that accumulation of oxidative damage may start in pre-symptomatic phases of AD pathology and that progression to AD might be related to depletion of antioxidant defenses.”

-J Alzheimers Dis. 2010 Aug 6.

So what does that mean.  Basically what this study found was that among patients who has mild cognitive impairment (MCI) or AD, people with the lowest levels of vitamin E had poorest performance on mental testing.  Oxidative damage is the process by which our brain tissue is broken down in AD.  Vitamin E helps fight this process.

Another study concluded:

“In conclusion, high plasma levels of vitamin E are associated with a reduced risk of AD in advanced age. The neuroprotective effect of vitamin E seems to be related to the combination of different forms, rather than to alpha-tocopherol alone.”

-J Alzheimers Dis. 2010;20(4):1029-37.

This is saying that higher levels of vitamin E in the blood were associated with a significant reduction in AD with advanced age.  It also says that when taking vitamin E you should be taking a combination of forms, not a singular type.  When you look at the back of your vitamin E supplement be sure that it says ‘mixed tocopherols.”  That will provide you with the most benefit.

Vitamin D

Vitamin D is the supplement of the hour right now.  It is being studied by everyone and just about everyone has found that it is critically important for overall health.  New research also shows it helps prevent AD.

“Vitamin D insufficiency and deficiency was associated with all-cause dementia, Alzheimer disease, stroke (with and without dementia symptoms), and MRI indicators of cerebrovascular disease. These findings suggest a potential vasculoprotective role of vitamin D.”

-Neurology. 2010 Jan 5;74(1):18-26. Epub 2009 Nov 25

This study is telling us that vitamin D insufficiency and deficiency was associated with higher risk for dementia and AD.  What this means is that even having levels that are slightly decreased (insufficiency) are associated with higher risk.  Keeping vitamin D levels up not only is important for bone health, cancer reduction and fall prevention but also reduces your risk of AD.  Pretty amazing stuff.

Another study on vitamin D found that:

“Clinical data suggest that vitamin D insufficiency is associated with an increased risk of several CNS diseases, including multiple sclerosis, Alzheimer’s and Parkinson’s disease, seasonal affective disorder and schizophrenia.  Overall, imbalances in the calcipherol system appear to cause abnormal function, including premature aging, of the CNS.”

– Psychoneuroendocrinology. 2009 Dec;34 Suppl 1:S278-86

This study is particularly interesting in that it shows that low vitamin D levels are associated with an increased risk of several CNS or central nervous system diseases including AD.  It also concluded that imbalances in the calcipherol, or vitamin D, system causes premature aging of the brain and central nervous system.  Why is this problematic?  Remember, the number one risk factor for AD is aging.  If we can slow this process, particularly in the brain, we can slow the onset of AD.  Vitamin D can do this for you.

Omega-3 Fatty Acids (Fish Oil)

“A plethora of in vitro, animal model, and human data, gathered over the past decade, highlight the important role DHA may play in the development of a variety of neurological and psychiatric disorders, including AD. Cross sectional and prospective cohort data have demonstrated that reduced dietary intake or low brain levels of DHA are associated with accelerated cognitive decline or the development of incipient dementia, including AD.”

-Clin Interv Aging. 2010 Apr 7;5:45-61.

DHA is a particular form of omega-3 fatty acid or fish oil.  This study concluded that low intake of this particular fatty acid or low brain levels of it are associated with cognitive decline and accelerated development of AD.  This is of particular interest because of all of the wonderful other benefits that omega-3’s give us.  You can prevent or reduce the risk of many other diseases simply by supplementing with fish oil.

There was this study as well:

“Plasma DHA was associated with slower decline on BVRT (Benton Visual Retention Test) performances in ApoE-epsilon4 carriers only. EPA and DHA may contribute to delaying decline in visual working memory in ApoE-epsilon4 carriers.”

-Neurobiol Aging. 2010 Jun 4.

This study was done on people who have the gene that is linked to an increased risk of AD.  What it concluded was very exciting.  Basically it found that the higher the omega-3 DHA was in the plasma the slower the decline in memory in people that were genetically predisposed to getting AD.  That’s wonderful news!  Many people think that their genetics are their destiny, but this study showed otherwise.

In Summary

This is just the tip of the iceberg in terms of research that is available on how to combat and reduce your risk of developing AD.  What we did not touch on in this article is that keeping your heart healthy and controlling your blood sugar is of utmost importance.  Do those things and take the supplements listed above and you can significantly reduce your risk of Alzheimer’s disease.

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