Tag Archives: statins

The Knock On Niacin – Big Pharma At It Again

Two new reports recently came out that said niacin, vitamin B3, is not effective for the prevention of heart disease or stroke. And, in fact, it might be dangerous. The studies also concluded that it might be so dangerous is shouldn’t be recommended at all. This is not an uncommon response when nutrients are studied, especially ones that reduce the market share for billion dollar statin medications.

Two studies recently published in the New England Journal of Medicine found that while niacin does reduce triglycerides, raise “good” (HDL) cholesterol, and reduce “bad” (LDL) cholesterol, it did not reduce the risk of heart attack or stroke.

Big PharmaI have several problems with the new information that’s been plastered all over the media recently about the recent studies:

Problem #1:

While two studies were performed, the largest of the two was funded by Merck Pharmaceuticals. It had over 25,000 participants while the other study, funded by the NIH, had just over 3,000 people. Merck clearly has an interest in driving down the sales of niacin as it would likely increase the sales of their cholesterol lowering drugs Zocor and Zetia. As an added note, niacin sales have tripled since 2002. Wouldn’t it be a perfect time to get a study that shows it’s dangerous or ineffective?

Problem #2:

These published trials do not reflect the clinical experience of doctors around the country who’ve been recommending niacin for decades. Research and a doctor’s clinical observations are often different. Which one do you believe?

Problem #3:

These trials focused on high-risk patients, almost all of whom were already taking statins and had low LDL levels. Would you see more benefit in clinical trials if these patients had different lipid profiles, or in those who did not already have heart disease? The populations they studied were already being treated intensively. It’s unlikely they were going to benefit by just one more treatment (niacin in this case).  As a matter of fact, in the Merck funded study they clearly state they cannot say whether niacin might be beneficial for patients at even higher risk of having a heart attack or stroke or those with higher LDL levels.

Problem #4:

Statins are particularly ineffective with potentially serious side effects, yet we don’t see reports on the news telling us to stay away from them. This is likely the powerful pull Big Pharma has on media and medicine. A full 98% of people who take statins see no benefit. Zero percent avoid death by taking a statin and only 1.6% avoid a survivable heart attack, and 0.4% are helped by preventing a stroke. Compare that to the side effects where 2% develop diabetes and 10% develop muscle damage as a result of taking that statin and the numbers don’t add up.

I think the real lesson of these studies (both on niacin and ones published on statins) is that inflammation, not necessarily the cholesterol itself, is the problem. If you address those factors, you will live a long, cardiovascular disease-free life.

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New Warning on Statins and Safe Alternatives

The FDA has come out with new warnings on statin medications.  The more we learn about these drugs, the clearer it becomes they are far over prescribed as the risk outweighs the benefit in many people who are taking them.

Read the transcript:

Hi everybody, this is Dr. Court bringing you another 90 Seconds of Knowledge. Today we’re going to talk about statin medications. This is the most popular class of drugs in the US and people use it to lower their cholesterol levels. And, potentially, although the evidence is not very good, reduce the evidence or the occurrence of heart disease.

Yesterday the FDA’s come out without new warnings. Number one, statins can potentially cause memory loss, confusion and other cognitive deficits. This may take a few weeks or a few years to manifest, and I’ve actually seen this in my patients. We get them off the statins and they do very well. Their cognitive abilities come right back so, it is apparently reversible.

The other warning is it does increase the risk of diabetes. It increases the risk of diabetes pretty significantly. It actually increases it by 27%. That’s a problem because diabetes significantly increases the risk of heart disease, the very thing that statins are supposed to protect us against.

It also increases HA1C or hemoglobin A1C. So, what that means is it prevents you from controlling your blood sugar very well, which is a big problem.

So, if we can’t use statins, what do we do?  Well, first diet and exercise. Those are the biggies. That’s really where we should focus. But if we do need some additional assistance there are some natural substances that work very well. Red yeast rice is one that is a natural statin. It is not without side effect. It is very much lower in side effect anyway, but you should always take CoQ10 when you’re taking any kind of statin whether synthetic or natural like red yeast rice.

There is niacin. Niacin works very, very well. Good old B3. It works exceptionally well. It lowers LDL’s. It lowers total cholesterol. What we want to focus on is the LDL.  And it also lowers lipoprotein A, a very dangerous, particular kind of cholesterol.

There are plant sterols. Plant sterols act by binding up the cholesterol that we eat and preventing us from absorbing it. There are medications that do that but the plant sterols are something that you can buy over the counter.

And then, of course, good old fish oil. We can’t talk about it enough. Fish oil has so much benefit. It reduces cardiovascular disease mortality better than anything. And, it reduces sudden cardiac death by 90%. It’s very, very effective. So, if you do one thing, take some fish oil.  Those are your options. The statins are still out there and they do have side effects but some of the natural options tend to have a lower side effect profile.

If you have any questions, let us know. We’ll be happy to answer them.

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Fast Food Chains To Offer Statins With Their Meals?

Below is a blog post from cnn.com.  It simply amazes me that a peer reviewed journal would suggest that fast food companies offer statins with their meals to offset their horrible health effects.  See my comments at the end of the article.

CNN Blog Post

A new report in the American Journal of Cardiology suggests that fast food restaurants should offer statins – a popular class of cholesterol-lowering medications – alongside their unhealthy food.

“We propose that the fast food industry is well placed to offer advice and supplements to counteract the cardiovascular harm arising from the foods they purvey,” the report said. “These companies already have an infrastructure for providing a variety of condiments… A generic statin could be added to the panoply of items in the self-service tray at little additional cost.”

The study – which likened taking a statin before eating to putting on a bike helmet before biking – was based on analyses of other scientific studies, and concluded that taking the drugs could offset the risk of eating fast food just enough to render the food harmless.

“Most of the primary prevention statin regimes we examined, with the exception of pravastatin, had the strength to counteract the increase in risk caused by an unhealthy diet; or eating an additional 36 g[rams] of total fat or 2.8 g[rams] of trans fat per day – approximately equivalent to a Quarter Pounder with cheese and a small milkshake,” the British researchers said in the study.

But Dr. Ralph Sacco, president of the American Heart Association, says that not only isn’t the solution that simple, it could be dangerous.

“There are other things regarding obesity that are important that a statin won’t neutralize, such as diabetes and high blood pressure,” Sacco said. “Even though we agree statins have a lot of good evidence in reducing cardiovascular and stroke risk, there are certain risks with any medications.”

The risks are relatively infrequent but include liver damage, muscle cramps and long-term muscle damage.

The British researchers concluded that the risks of eating fast food are much greater.

“Statins have been shown to be safe even at high doses,” the report says. “The documented safety record of statins is substantially better than that of fast foods, which carry not only direct cardiovascular risks, but other risks due to obesity.”

But regardless of whether the benefits do in fact outweigh the risks,  Sacco says there are far better ways to reduce the negative effects of obesity.

“If you can control it with diet and exercise, that would be our preference rather than having to take a medicine.”

Dr. Court’s Comments

This is perhaps the most ridiculous recommendation I have ever seen from a mainstream medical publication.  They are suggesting that fast food chains offer cholesterol lower medications, called statins, with their meals to offset the negative health effects they have on human physiology. This is the pinnacle of not taking responsibility for one’s health.  Why take responsibility if you can take a pill to supposedly offset the detriments to your health from eating the most unhealthy foods in the world?

Statin medications are not as safe as Big Pharma would like you to believe. Statins are HMG-CoA reductase inhibitors, that is, they act by blocking the enzyme in your liver that is responsible for making cholesterol (HMG-CoA reductase). The fact that statin drugs cause side effects is well established—there are now 900 studies proving their adverse effects, which run the gamut from muscle problems to increased cancer risk.

For starters, reported side effects include:

  • Muscle problems, polyneuropathy (nerve damage in the hands and feet), and rhabdomyolysis (a serious degenerative muscle tissue condition)
  • Anemia
  • Acidosis
  • Sexual dysfunction
  • Immune depression
  • Pancreas or liver dysfunction, including a potential increase in liver enzymes
  • Cataracts

These side effects hardly seem harmless and to give them as an option with your value meal from McDonald’s is outrageous.  It is a great marketing ploy by the pharmaceutical industry to get as many American’s on statins as possible.  Think about it.  Wouldn’t this kind of strategy significantly increase sales of statin drugs?  Of course it would.  And where do we start and stop giving them to people.  Does a 3 year old eating a happy meal get a statin to go with it?  What about people who are already taking statins?  Do they just take extra because you really never can get to much medication can you?  The slope is a slippery one and I cannot believe this has even been suggested.

I was happy to see the president of the American Heart Association take the other side of this story.  He mentions that statins do nothing to offset the other health complications of fast food like diabetes and high blood pressure.  This is true.  You can’t take a statin to avoid diabetes.  What he doesn’t mention is the fact that those kinds of food – food high in refined sugar – are notorious for raising inflammation in the body.  When you raise inflammation you raise the risk of heart disease, stroke, cancer and osteoporosis to name just a few.  You can’t control inflammation by taking a statin.  Some new research does suggest that statins lower one of the inflammatory enzymes called CRP.  But that’s just one.  There are others that are still detrimental to one’s health.

This kind of a recommendation is dangerous.  Period.  It is also irresponsible for the American Journal of Cardiology to publish such information.  It plants a dangerous seed.  This kind of a recommendation encourages people to continue to make poor decisions regarding their diets.  It gives them an excuse to continue to destroy their health under the pretense that they are offsetting their bad decisions with a pill.  Instead, we should be encouraging people to make healthier choices regarding their diet and lifestyle.

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