Monthly Archives: October 2015

Fat, sugar cause bacterial changes that may relate to loss of cognitive function

A study at Oregon State University indicates that both a high-fat and a high-sugar diet, compared to a normal diet, cause changes in gut bacteria that appear related to a significant loss of “cognitive flexibility,” or the power to adapt and adjust to changing situations. This effect was most serious on the high-sugar diet, which also showed an impairment of early learning for both long-term and short-term memory. The findings are consistent with some other studies about the impact of fat and sugar on cognitive function and behavior, and suggest that some of these problems may be linked to alteration of the microbiome — a complex mixture in the digestive system of about 100 trillion microorganisms. The research was done with laboratory mice that consumed different diets and then faced a variety of tests, such as water maze testing, to monitor changes in their mental and physical function, and associated impacts on various types of bacteria. The findings were published in the journal Neuroscience, in work supported by the Microbiology Foundation and the National Science Foundation. “It’s increasingly clear that our gut bacteria, or microbiota, can communicate with the human brain,” said Kathy Magnusson, a professor in the OSU College of Veterinary Medicine and principal investigator with the Linus Pauling Institute. “Bacteria can release compounds that act as neurotransmitters, stimulate sensory nerves or the immune system, and affect a wide range of biological functions,” she said. “We’re not sure just what messages are being sent, but we are tracking down the pathways and the effects.” Mice have proven to be a particularly good model for studies relevant to humans, Magnusson said, on such topics as aging, spatial memory, obesity and other issues. In this research, after just four weeks on a high-fat or a high-sugar diet, the performance of mice on various tests of mental and physical function began to drop, compared to animals on a normal diet. One of the most pronounced changes was in what researchers call cognitive flexibility. “The impairment of cognitive flexibility in this study was pretty strong,” Magnusson said. “Think about driving home on a route that’s very familiar to you, something you’re used to doing. Then one day that road is closed and you suddenly have to find a new way home.” A person with high levels of cognitive flexibility would immediately adapt to the change, determine the next best route home, and remember to use the same route the following morning, all with little problem. With impaired flexibility, it might be a long, slow, and stressful way home. This study was done with young animals, Magnusson said, which ordinarily would have a healthier biological system that’s better able to resist pathological influences from their microbiota. The findings might be even more pronounced with older animals or humans with compromised intestinal systems, she said. What’s often referred to as the “Western diet,” or foods that are high in fat, sugars and simple carbohydrates, has been linked to a range of chronic illnesses in the United States, including the obesity epidemic and an increased incidence of Alzheimer’s disease. “We’ve known for a while that too much fat and sugar are not good for you,” Magnusson said. “This work suggests that fat and sugar are altering your healthy bacterial systems, and that’s one of the reasons those foods aren’t good for you. It’s not just the food that could be influencing your brain, but an interaction between the food and microbial changes.”

Source: Fat, sugar cause bacterial changes that may relate to loss of cognitive function — ScienceDaily

 

 

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3 Things That Happen To Your Brain With Leaky Gut

Gut health is essential for overall health. That connection is fairly easy to make. But what about your brain? Can the health of your gut really affect your brain? The answer is a resounding yes! Here are three things that happen to your brain when you have a leaky gut.

  1. Depression – the bacteria that naturally exist in our GI tract are mostly beneficial. However, if metabolic byproducts and cell constituents are able to escape the gut they cause a potent inflammatory response. This happens through a “leaky gut.” The resulting response alters levels of inflammatory hormones called cytokines. These cytokines have the ability to communicate with the brain and eventually change neurotransmitter levels. This change in neurotransmission actually begins to rewire the brain leading the changes in how we think and feel. Most often, people begin to feel depressed. 3.02-brain-on-fire
  2. An Inflamed Brain – through the mechanisms just mentioned, not only do your neurotransmitters and thoughts/feelings change, your brain becomes inflamed. This signals the immune cells within the brain, called glial cells, to become very active. This may sound like a good thing, but it’s not. As a result of being activated glial cellsgenerate more inflammation and create oxidative stress. This means the glial cells begin breaking down the brain. This may increase your risk of brain fog, fatigue, depression, anxiety, cognitive decline, and possibly even neurodegenerative disorders like Parkinson’s disease and Alzheimer’s disease.
  3. Blood Brain Barrier Breakdown – there is a barrier than exists that separates what is circulating in our blood from our brain. Only things that are beneficial for the brain are supposed to have access to it. The blood brain barrier is an exceptionally important structure. With increased inflammation from a leaky gut and glial activation, the blood brain barrier breaks down. Now toxic byproducts, inflammatory hormones, and other noxious chemicals have free access to the brain. This is a disastrous consequence that interferes with brain function leading to a multitude of symptoms which include depression, brain fog, anxiety, and more. Leaky gut leads to a leaky blood brain barrier!

Gastrointestinal health is essential for brain health. Knowing how to fix the gut can lead to dramatic improvements in how you feel cognitively and emotionally.

For much more information and strategies to improve your gut and brain health join me for a FREE webinar on Tuesday, November 10th at 7:30PM called “The Gut-Brain Connection – Mood, Food, and More!” We’ll explore the amazing connection between gut health and brain health and give you tips and tricks to make both healthy.

Dr. Vreeland is a nationally recognized expert and author in functional medicine and will present information that will be life changing! You don’t want to miss this event!

Click here to register: http://www.anymeeting.com/PIID=EC51D98085463A

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